Formulation and Characterization of a New Injectable Bone Substitute Composed PVA/Borax/CaCO3 and Demineralized Bone Matrix

The occurrence of bone-related disorders and diseases has dramatically increased in recent years around the world. Demineralized bone matrix (DBM) been widely used as a implant due to its osteoinduction bioactivity. However, use DBM is limited because it particulate material, which makes difficult manipulate with precision. In addition, these particles are susceptible migration other sites. To address this situation, commonly incorporated into variety carriers. An injectable scaffold advantages over grafts or preformed scaffolds, such ability flow fill defect. aim research was develop carrier viscoelastic properties order obtain an substitute (IBS). developed consisted PVA/glycerol network cross-linked borax reinforced CaCO3 pH neutralizer, porosity generator, source Ca. physicochemical were determined by injectability test, FTIR, SEM, TGA. Porosity, degradation, bioactivity, possible cytotoxic effect, proliferation osteoblasts also determined. results showed that material great potential be tissue regeneration.